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By study’s end, the Epidiolex group had a median 39 percent reduction in the number of convulsive seizures in a month, while the placebo group had a 13 percent reduction. It was a difference the researchers called highly statistically significant.
Epidiolex, however, would be the first proposed drug made solely from cannabidiol, the plant’s second major chemical component, though one that’s steadily being bred... Read More

Every case of epilepsy is different and the disease is highly variable. Scientific studies help the entire epilepsy community to understand how and why various treatments work and for whom they are effective. Research also helps us understand the correct dose, side effects, and potential interactions with other medications. At present, the epilepsy community does not know if marijuana is a safe and effective treatment nor do we know the long-term effects
that marijuana will have on... Read More

The American Academy of Child and Adolescent Psychiatry (AACAP) advocates for careful consideration of potential direct and downstream effects of marijuana policy changes on children and adolescents, and involvement of the medical and research community in policy-related discussions.  Legalization of marijuana for medicinal or recreational purposes, even if restricted to adults, is likely to be associated with (a) decreased adolescent perceptions of marijuana’s harmful effects, (b) increased... Read More

Drug use impacts any person's ability to get a job far more than their arrest record. Several suggestions were offered to help make this citation an avenue for reducing future drug use and criminal activity.

WHEREAS, the legalization of marijuana would be contrary to the interests of the public health, safety and welfare, and would undermine the quality of life of the citizens of the state of Florida.

"Many adolescents and young adults hear that marijuana is harmless," Miller said. "This is a myth. Research shows that the brain continues to grow until the age of 25. Marijuana is extremely harmful to the developing brain."
Officials in St. Petersburg also have discussed a similar de-escalation of the war on this particular drug. Last year, Miami-Dade, Miami Beach, Fernandina Beach and Hallandale Beach all launched citation programs.

The National Narcotic Officers’ Associations’ Coalition (NNOAC) opposes all efforts at the local, state, and Federal levels to decriminalize, legalize, or normalize marijuana possession, production, and use, including legalize “medical” marijuana.

Marijuana is a dangerous psychoactive substance that has caused untold pain and suffering to individuals, families, and communities. 

Medina's back seat passenger, Daniela Benavides San Miguel, 18, was killed in the crash. Benavides San Miguel had graduated from Gulliver Preparatory last spring and was a freshman at Pepperdine University in California.
A passenger in the front seat, Mathew Saldana, 17, was injured in the crash. Medina and Saldana were taken to Jackson Memorial Hospital's Ryder Trauma Center with head injuries.
According to a court document, toxicology reports showed that Medina tested positive... Read More

The simple fact that THC is fat soluble. That makes it absorbed in a very different way and much more difficult to relate behavior to, say, [blood] levels of THC or develop a breathalyzer."  The height of your intoxication isn't at the moment when blood THC levels peak, and the high doesn't rise and fall uniformly based on how much THC leaves and enters your bodily fluids, says Marilyn Huestis, who headed the chemistry and drug metabolism section at the National Institute on Drug Abuse.

Acceptance of employee marijuana use means increased accidents and injuries, loss of workplace productivity, increased workers' compensation claims, and employee turnover, to name a few problems (National Institutes of Health). These losses have real dollar value that impacts small-business owners considerably. Ultimately, the most costly battles will be fought in the courts at the employers' expense. Weakening or removing employers' rights for a safe and drug free workplace ultimately... Read More

DENVER — The Colorado Department of Transportation says traffic deaths rose by 10 percent last year to 545, the highest total since 2008.
 
#NoCoincidence  

Five companies were awarded licenses in November to grow and distribute the new low-THC forms of the drug and some have now hired lobbyists. Costa Farms, a giant Miami-based grower of fruits and vegetables, wants to expand the list of ailments for which low-THC marijuana can be prescribed so it can broaden its market. It gave $88,000 to the political committees of the top players, including $35,000 each to the sponsors of their bills -- Sen. Rob Bradley, R-Fleming Island and Rep. Matt Gaetz... Read More

The good news, however, is to be found in the very restrictive guidelines they have imposed, including prohibiting smoking it, and pot edibles, as well as Not including psychological issues as debilitating conditions, ie  PTSD, or "pain" to justify physician recommendation for patients. There is also no providing immunity for physicians or dispensers for civil liability. Patient warnings on the packaging are also required because of the risks of use, including addiction. While it is still... Read More

"At a minimum, dabs are four times as strong as a joint, and the high is administered all at once,"

January 2016 Update:
YOUTH USAGE: 
• In the two year average (2013/2014) since Colorado legalized recreational marijuana, youth past month marijuana use increased 20 percent compared to the two year average prior to legalization (2011/2012). o Nationally youth past month marijuana use declined 4 percent during the same time.
• The latest 2013/2014 results show Colorado youth ranked #1 in the nation for past month marijuana use, up from #4 in... Read More

Although studies are beginning to show that some ingredients in marijuana are likely to be helpful for people with certain conditions, the findings have yet to nail down the specifics about the dose, the frequency, the best form to take (such as getting the active compounds from edible products or smoking it), the risks from frequent use, and whether marijuana works as well as or better than other available treatments, Budney said.
Usage Doubles & Addiction... Read More

Analysis of Impaired Drivers - Three years ago, about 19 percent of the samples contained THC, the key ingredient in pot. This year, that percentage is up to 33 percent.  

The evidence of harm, however, is only getting clearing. And the latest rise in use, addiction and death by car crash numbers add clarity to the picture of harms associated with widespread use of the drug.

These results from an uncontrolled study support the animal studies and prior reports showing that CBD may be a promising treatment for TRE and it is generally well-tolerated in doses up to 25mg/kg/day. Epidiolex is now being investigated in randomized controlled studies in DS and LGS.

According to Kevin Merill, the Drug Enforcement Agency (DEA) officer in charge in Denver, "more and more criminals are moving to Colorado to exploit our drug laws, sell marijuana through the U.S. and line their pockets with drug money."
The Colorado experience is certainly troubling and has not been the panacea purported by legalization advocates.
In 2010, medical marijuana was legalized in Colorado.  In 2012, it legalized marijuana and in 2014 retail businesses began selling it... Read More

"We found that frequent use of high-potency cannabis significantly affects the structure of white matter fibres in the brain, whether you have psychosis or not," 
The main psychoactive ingredient in weed, tetrahydrocannabinol (THC), is much more concentrated in modern skunk strains as compared to traditional pot and hash -- up 14 percent as compared to 4 percent.

And yes, my friends, there are many problems associated with use of marijuana, such as the risk of addiction, risk for vehicle crashes, emergency department visits, psychiatric symptoms, poor quality of life, cognitive decline, and the use of other drugs.
Marijuana’s immediate effects include distorted perception, difficulty with thinking and problems solving, and loss of motor coordination. Marijuana use can also cause space and time distortion, delusional thinking, and even... Read More

By the end of 2014, the number of total crimes was 24 percent higher than in 2012. Property crimes increased 14 percent... Read More

Children whose mothers use marijuana during pregnancy have a higher risk of stunted growth and of developing ADHD, anxiety, and depression later in life.
When THC enters the body, it interferes with endocannabinoid’s actions, competing with it for binding sites on target cells and generally getting its way.

 “It is important to know that legalizing marijuana would not mean greater access to potentially effective treatment for children and adults with a medical illness such as epilepsy. Cannabidiol, or CBD, is not at all marijuana.”

CBD is not medical marijuana. CBD does not get anyone high nor does it increase appetite. It may be beneficial in treating children with rare forms of epilepsy, often difficult to control with... Read More

The project is intended to treat 50 children from ages 2 to 16 living with epilepsy that have exhausted most of their treatment options, Carney said.
Every step of the three-year study will be meticulously tracked. Patients will check-in at regular intervals and the researchers will examine how the children are responding, Carney said.
All subjects will be clinically evaluated and seizure frequency will be recorded in a diary given to patients, according to the ... Read More

1. The first major change involves the rising concentrations of tetrahydrocannabinol (THC).As the potency of this drug increased over time, a number of thresholds of toxicity have been exceeded.
2. The anxiety and depression problems resulting from THC consumption are nothing new, but they are much more common now. (I have seen more cases in the last year than in the 4 years prior combined.)
3. Schizophrenia:  All who have suffered this complication have experienced a major... Read More

More Positive Results With Cannabidiol in Epilepsy (You will need to google this title in order to get the article to avoid creating an account)
They found a reduction of the total number of seizures by a median of 38% at 3 months and 31% at 6 months.
These patients started on a cannabidiol (CBD) dose of 2 mg/kg per day, which was increased to a maximum tolerated dose or to 25 mg/kg per day.
Of the 25 patients enrolled in the study, two discontinued treatment before 6... Read More

Adolescent cannabis use increased the odds of non-progression with formal education.

• ... Read More

§Puff for puff, smoking marijuana is more dangerous than smoking cigarettes.  http://162.99.3.213/products/manuals/matrix/ppt/marijuana.ppt

• 22.2 million (8.4%) people were current (past month) users of marijuana in 2014, making it the most used illicit drug.
• Marijuana use was most prevalent among people age 18 to 25 (with 19.6% using it in the past month).
• 7.4% of... Read More

 But at a bare minimum, these findings suggest we should be avoiding recreational cannabis use during pregnancy. 

Is legal 'medical' marijuana linked to high youth substance abuse rates?

Let's look at Colorado's substance abuse rates in 2011- 2012 when medical marijuana was legal but recreational pot was not,... Read More

Kembel's is the highest-profile death associated with cannabis since it became legal for adults to purchase recreational marijuana in Oregon last week. Police said Tuesday it was unclear to what extent marijuana impairment had been a factor in the crash.

At the moment, there simply isn’t enough evidence to prove that cannabinoids – whether natural or synthetic – works to treat cancer in patients, although research is ongoing. And there’s certainly no evidence that ‘street’ cannabis can treat cancer.

Levy says. “We are simply not prepared for the fallout of marijuana legalization.”
Each hit of THC rewires the function of this critical cognitive system: Early evidence in mice has shown that repeated exposure to THC causes these receptors to disappear altogether, blunting the natural response to positive behaviors and requiring higher doses to achieve the same effect. Marijuana exploits essential pathways we’ve evolved to retrieve a memory, to delicately regulate our metabolism, and... Read More

“I think we’re going to be seeing a lot of similar lawsuits in other states,” Malsbury said, pointing out that the nation’s largest marijuana producer, California, has no pot regulations at all. Medical marijuana is grown and sold in California but recreational sales remain against state law.

“Every state must take steps to reduce drug-impaired driving, regardless of the legal status of marijuana,” said Jonathan Adkins, Executive Director of GHSA. “This is the first report to provide states and other stakeholders with the information they need. And we encourage NHTSA to issue guidance on best practices to prevent marijuana-impaired driving. We look to the federal government to take a... Read More

A quadrupling in the use of prescription drugs since 1999, and legalization of marijuana use in some states are cited among the reasons drug use has become an increasing threat to roadway safety, according to a report released today by the Governors Highway Safety Association, an organization of state highway safety officers.

Background Paper on Legalization of Marijuana for Medical Use  Prepared for the Members of the Georgia Medical Cannabis Commission by National Families in Action
1.... Read More

Olympia, WA – Newly released data from the Washington Traffic Safety Commission (WTSC) shows that marijuana is increasing as a factor in deadly crashes. The number of drivers involved in deadly crashes who tested positive for marijuana increased 48 percent from 2013 to 2014. 
“This study is a step towards answering the myriad of questions we have about the impact of legalized marijuana on driving.

Given these statistics.... is legalization worth the consequences....
Cannabis has been found to be the most frequently used drug in the U.S. after alcohol, tobacco and caffeine. 
The risk of developing addiction associated with cannabis use has been reported to increase to about 17% among those who start using marijuana in adolescence, and to 25-50% among those who smoke marijuana daily.
The long-term effects of marijuana use include altered brain development and cognitive... Read More

The commonly heard expression that “no one ever died from a marijuana overdose” minimizes the cost of unmet potential and inability to fully engage in the challenges of daily life. Scientific research cites multiple impacts of the recreational misuse of marijuana.

Positive top-line results have been reported from an exploratory phase 2a placebo-controlled clinical trial of cannabidiol (CBD, GW Pharmaceuticals) in patients with schizophrenia who had failed to respond adequately to first-line antipsychotic medications.  DOES NOT CONTAIN THC.