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Significant effects of prenatal cannabis exposure have been found on children's sleep, cognitive functions (memory and scholastic skills), as well as on executive (frontal lobe) functions (reasoning, attention, impulsivity, and motivation), and affective (depression) and anxiety symptoms throughout the stages of development. Following the presentation of two case vignettes, we integrate the published information on outcomes of maternal use of cannabis during pregnancy on the developing fetus and the "soft" neurological deficits and neuro-behavioral disturbances manifested by them from early childhood and evolving to peaks in adolescence. Taken together, these data serve to define what we call a heretofore unspecified "fetal cannabis spectrum disorder".

Researchers say psychoactive compounds in marijuana easily cross the placenta, exposing the fetus to perhaps 10 percent of the THC — tetrahydrocannabinol — that the mother receives, and higher concentrations if the mom uses pot repeatedly.

CONCLUSIONS:
Early cannabis use is associated with psychosis-related outcomes in young adults. The use of sibling pairs reduces the likelihood that unmeasured confounding explains these findings. This study provides further support for the hypothesis that early cannabis use is a risk-modifying factor for psychosis-related outcomes in young adults.

The authors discovered several interesting things. First, all elements of both alcohol and cannabis use increase annually across the various levels of frequency of use, with the exception of daily alcohol use. Second, the effects of cannabis are considerably greater than those of alcohol. Third, there appear to be both concurrent and lagged effects of cannabis use on several cognitive domains. Thus, use of cannabis has persistent effects that are also exacerbated by continued use.

Experts define addiction as continued marijuana use despite negative consequences in a person's life, such as issues relating to their family, job, or relationships.
People who use marijuana regularly and then stop abruptly can experience some withdrawal symptoms.

Given today's concerns about maintaining a healthy body eating organic foods, low carb diets, ... reading all the labels to verify safety and good health, it is ironic the same standards are not demanded by those that consume marijuana.  Dog food is safer than marijuana!

For example, smoking pot is widely supposed to diminish the nausea associated with chemotherapy. But, the panel pointed out, “there are no good-quality randomized trials investigating this option.” We have evidence for marijuana as a treatment for pain, but “very little is known about the efficacy, dose, routes of administration, or side effects of commonly used and commercially available cannabis products in the United States.” The caveats continue. Is it good for epilepsy? “Insufficient evidence.” Tourette’s syndrome? Limited evidence. A.L.S., Huntington’s, and Parkinson’s? Insufficient evidence. Irritable-bowel syndrome? Insufficient evidence. Dementia and glaucoma? Probably not. Anxiety? Maybe. Depression? Probably not.

“dose-response relationship”... non-existent!

Large-scale, longitudinal studies of humans whose mothers smoked marijuana once or more per week and experimental work on rodents exposed to cannabinoids in utero have yielded remarkably consistent intellectual and behavioral correlates of fetal exposure to this drug. Some exposed individuals exhibit deficits in memory, cognition, and measures of sociability. These aberrations appear during infancy and persist through adulthood and are tied to changes in the expression of multiple gene families, as well as more global measures of brain responsiveness and plasticity. Researchers currently consider these perturbations to be mediated by changes to the endocannabinoid system caused by the active compounds in cannabis. 

In summary, when approaching how to define the threshold to report a family to a child welfare system, we must first take into account our state laws. Our medical opinion, however, must be directed by many other factors, including an understanding of the circumstances and the motivation of the parent. Child welfare systems rely on medical providers to make clear statements regarding our medical opinion about whether a child has been abused or neglected. This is a powerful role. We might also use this case to advocate for a change in state laws or policies regarding the well-intentioned use of marijuana in dire circumstances such as the ones that this mother faced.

The advisory mentions the following risks:
1. Marijuana is addictive. Approximately one in eleven individuals who use marijuana will become addicted. The risk is greater in youth. One in six teenagers who use marijuana will become addicted, and the risk for developing a marijuana substance use disorder further increases for those who use marijuana frequently.....

• Marijuana is addictive. Approximately one in 11 adults who use marijuana will become addicted, and the risk of addiction is greater among youth.  
• Marijuana now available is more potent with greater levels of tetrahydrocannabinol, or THC, the primary psychoactive substance in Cannabis than marijuana available in previous decades. The long-term health or developmental consequences of exposure to these high concentrations of marijuana are unknown.
• Marijuana use is associated with adverse health outcomes including development of psychoses like schizophrenia and increased risk of motor vehicle crashes.....

When mothers use marijuana during the first 12 years of their child's life, their cannabis-using children are more likely to start at an earlier age than children of non-using mothers, according to a new study from the Harvard T.H. Chan School of Public Health published in the American Journal of Preventive Medicine. This study is the first to establish a relationship between maternal cannabis use during a child's lifetime and earlier initiation in a nationally-representative, longitudinal cohort and examine the role of race, gender, and other social environmental factors.

There was more alarming news. Use of illegal drugs, including cocaine, marijuana, and opioids by pregnant women increased significantly between 2015 and 2017. About 7 percent of pregnant women reported using marijuana. Three percent said they used it daily. 

McCance-Katz says marijuana use is linked to fetal growth problems, preterm births, stillbirths, hyperactivity and impaired cognition in newborns. 

In conclusion, cannabis use is common in people with chronic non-cancer pain who have been prescribed opioids, and interest in medicinal use of cannabis is increasing. We found no evidence that cannabis use improved patient outcomes; those who used cannabis had greater pain and lower self-efficacy in managing pain. Furthermore, we found no evidence that cannabis use reduced pain interference or exerted an opioidsparing effect.

Over the past several years, FDA has issued several warning letters to firms that market unapproved new drugs that allegedly contain cannabidiol (CBD). As part of these actions, FDA has tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to contain. It is important to note that these products are not approved by FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease. Consumers should beware purchasing and using any such products.

The importance of the published findings and the emerging research regarding the potential negative effects of marijuana on brain development are a cause for concern despite the limited research and are the basis for the following recommendations:

1. Women who are considering becoming pregnant or who are of reproductive age need to be informed about the lack of definitive research and counseled about the current concerns regarding potential adverse effects of THC use on the woman and on fetal, infant, and child development. Marijuana can be included as part of a discussion about the use of tobacco, alcohol, and other drugs and medications during pregnancy.
2. As part of routine anticipatory guidance and in addition to contraception counseling, it is important to advise all adolescents and young women that if they become pregnant, marijuana should not be used during pregnancy.
3. Pregnant women who are using marijuana or other cannabinoid-containing products to treat a medical condition or to treat nausea and vomiting during pregnancy should be counseled about the lack of safety data and the possible adverse effects of THC in these products on the developing fetus and referred to their health care provider for alternative treatments that have better pregnancy-specific safety data.
4. Women of reproductive age who are pregnant or planning to become pregnant and are identified through universal screening as using marijuana should be counseled and, as clinically indicated, receive brief intervention and be referred to treatment.
5. Although marijuana is legal in some states, pregnant women who use marijuana can be subject to child welfare investigations if they have a positive marijuana screen result. Health care providers should emphasize that the purpose of screening is to allow treatment of the woman’s substance use, not to punish or prosecute her.
6. Present data are insufficient to assess the effects of exposure of infants to maternal marijuana use during breastfeeding. As a result, maternal marijuana use while breastfeeding is discouraged. Because the potential risks of infant exposure to marijuana metabolites are unknown, women should be informed of the potential risk of exposure during lactation and encouraged to abstain from using any marijuana products while breastfeeding.
7. Pregnant or breastfeeding women should be cautioned about infant exposure to smoke from marijuana in the environment, given emerging data on the effects of passive marijuana smoke.
8. Women who have become abstinent from previous marijuana use should be encouraged to remain abstinent while pregnant and breastfeeding.
9. Further research regarding the use of and effects of marijuana during pregnancy and breastfeeding is needed.
10. Pediatricians are urged to work with their state and/or local health departments if legalization of marijuana is being considered or has occurred in their state to help with constructive, nonpunitive policy and education for families.

A Canadian love-fest for Florida pot companies continues to blossom with a $93 million deal that includes a Ruskin-based grower yet to begin selling marijuana products.
 
In your recent article, Canadian firm strikes a deal to enter Florida marijuana market with Ruskin grower, you have a picture of medical marijuana in a pill bottle and with a prescription pad.  MEDICAL MARIJUANA in this form IS NOT A PRESCRIPTION AND IS NOT FDA APPROVED.. NOR DO ANY MEDICAL ASSOCIATIONS SUPPORT THIS FORM OF MEDICATION.  Please show it for what it is a bag of pot with a label 'medicine'.  #FasleHope #FakeMedicine

First and foremost, marijuana is already associated with more abuse and dependency (now called substance abuse disorder) than all other illegal drugs combined. Roughly four out of seven problem usersof illegal drugs are using marijuana. This is a dangerous blind spot exploited by many legalization advocates (although some of them are now warning about the growing risk of heavy marijuana use under legalization)....

The preliminary figures show that 959 people died in Colorado last year from drug poisoning, a figure that includes both intentional and unintentional overdoses. In 2016, 912 people died. In 2000, for comparison, drug poisonings claimed fewer than 400 lives.

We found that among young recreational cannabis users, a regular dose of cannabis had no effect on simple and learned tasks, but its use led to significant impairments on complex and novel driving-related tasks, as well as perceived driving ability and safety, for up to 5 hours after use. The present finding that the first 5 hours after cannabis use affected driving-related performance substantiates the recommendations of Canada’s Lower-Risk Cannabis Use Guidelines, which recommend waiting 6 hours after cannabis use before driving.30
 

During the same time period that cigarette smoking around children came down more than 7%, marijuana smoking around children went up nearly 5%. With more and more states legalizing marijuana for recreational use, that number is likely to continue going up.
This is not good. Besides the fact that we don’t want children getting high, or exposed to the dangers of inhaled secondhand marijuana smoke, there is the additional concern about long-term effects on the brain. While research is still ongoing, there is evidence to suggest that when youth and young adults (whose brains are still developing) are exposed to marijuana, it may have permanent effects on executive function, memory, and even IQ.

When we talk about legalizing marijuana, we must acknowledge that we are talking about legalizing a mind-altering substance that affects the brain by impairing cognition, judgment, and reflexes. We need to discuss the science and data behind the consequences of marijuana consumption on our youth and their developing brains, as this is an issue that is far-too-often overlooked.

Teens have taken a technology that was supposed to help grownups stop smoking and invented a new kind of bad habit, molded in their own image.

“Juul is already a massive public-health disaster—and without dramatic action it’s going to get much, much, much worse.”

Winickoff believes that the vape industry is co-opting the national wellness trend—“when, in fact, vaping can cause something called bronchiolitis obliterans, or popcorn lung,” he said. Popcorn lung has been linked to diacetyl, an organic compound that some companies use in their e-liquid, and that has been detected as a by-product of e-cigarette vapor. But diacetyl has also been detected in cigarette smoke, at a level hundreds of times greater, and no feasible amount of smoking has been found to cause popcorn lung. (Juul does not use diacetyl in its liquid, and, in tests, the company has found no measurable amounts of diacetyl in the vapor emitted by its devices.)

"Marijuana doctors were 2.8 times as likely as other doctors to have been disciplined by the Board of Medicine, and 2.4 times as likely to have been charged with a crime. Altogether, 108 of them were responsible for $69.4 million in malpractice judgments and settlements, some for maiming or killing patients. Some of the doctors have been fined, suspended or stripped of their licenses in other states. They’ve misdiagnosed conditions, falsified records and written prescriptions for people they never saw. They’ve been jailed for domestic violence. A few have sexually abused patients, including those as young as 14 and 16."

Researchers had two women conduct "mystery caller" phone conversations with employees at 400 dispensaries across the state, telling them that they were eight weeks pregnant and suffering from morning sickness. During the majority of those calls, the employees recommended the women use cannabis products.

I'm here to tell you this is not a safe drug," McCance-Katz said during a town hall event at "NatCon18," the National Council for Behavioral Health's annual conference.
"Americans have a right to know that and we should be telling them that," she continued.
And while tobacco and alcohol rates have declined among pregnant women in recent years, illicit drugs -- mainly marijuana but also opioids -- have increased from 78,000 women in 2015 to 111,000 in 2016, she said.
On the contrary, "marijuana use was associated with substantially increased risk of addiction and overdose for opioids," she said, citing research from Mark Olfson, MD, MPH, and colleagues in the American Journal of Psychiatry.
 
 

(TIME)  April 20, also known as “420,” is a day popular with many marijuanasmokers who see it as a “national holiday” of sorts and celebrate by getting high. The term “420” originated in the 1970s with a group of California high schoolers who would regularly meet after school at 4:20 p.m. to smoke weed.
 

Conclusions: Our findings disconfirm the hypothesis that a population-level negative correlation between medical marijuana use and prescription drug harms occurs because medical marijuana users are less likely to use prescription drugs, either medically or nonmedically. Medical marijuana users should be a target population in efforts to combat nonmedical prescription drug use.

Conclusion: This study provides evidence that cannabis use, especially when initiated at a young age, may be associated with worse verbal memory and altered neural development along the UF. Reductions in cortical thickness in regions implicated in memory processes may underlie weaknesses in verbal memory performance.

From 2005 to 2015, 4,202 marijuana-related visits were identified. Behavioral health evaluation was obtained for 2,813 (67%); a psychiatric diagnosis was made for the majority (71%) of these visits. Coingestants were common; the most common was ethanol (12%). Marijuana-related visits increased from 1.8 per 1,000 visits in 2009 to 4.9 in 2015. (p = < .0001) CONCLUSIONS: Despite national survey data suggesting no appreciable difference in adolescent marijuana use, our data demonstrate a significant increase in adolescent marijuana-associated emergency department and urgent cares visits in Colorado.

It is a sham that expands the conditions that qualify an individual for “medical marijuana” to any condition and for any person, no matter of age. It is a scheme to establish a system of “fake” medicine to further the game plan of the marijuana industry for full commercialism that will allow anyone for any reason to buy marijuana for the high they desire and the profit the industry demands. It is now up to the Vermont House to recognize what is happening and stop it before it is too late.

Overall, while less dangerous than opioids by far, and possibly helpful for some conditions, including pain, no findings, to my knowledge, clearly demonstrate that marijuana use positively impacts people with opioid use disorder. Moreover, marijuana use carries risks, including cannabis use disorder, psychosis and cognitive impairment, as well as additive effects when used with other substances, including opioids.

Kara Macek, spokeswoman for the GHSA, said the organization could point to several possible factors in the high level of fatalities: increased exposure to danger as more drivers hit the road and more people move to urbanized areas, an uptick in distracted driving from cellphone use, or even an increase in accidents in states that have legalized recreational marijuana use.
The GHSA report noted that in some states that have legalized recreational marijuana — Alaska, Colorado, Maine, Massachusetts, Nevada, Oregon, Washington and the District of Columbia — pedestrian fatalities went up 16.4 percent in early 2017, while all other states saw a 5.8 percent drop.
“We lack causation data, but can see a correlation,” Macek said. “This is a red flag we need to look at as a country. We don't have a position on marijuana legalization, but we do have a position on getting people home safely.”

Marijuana use is associated with an increased risk of prescription opioid use.  
Marijuana use seems to strengthen the relationship between pain and depression and anxiety, not ease it.

"Every person I've ever asked that has a drug addiction problem, I would ask them intentionally 'what was your drug of choice that set you on this path?' Marijuana. Every time, marijuana," Judd said.
He went on to say that when you look at all the drugs killing people and contributing to drug related deaths, "leaving marijuana out of the recipe would be a horrible mistake."

“The violence is there with other drugs, but we don’t see the homicides associated with other narcotics as we do with marijuana,” said Anoka County Sheriff’s Lt. Wayne Heath, commander of the Anoka-Hennepin Narcotics and Violent Crimes Task Force. “No one knows why in marijuana it leads to that extra step.”

An 11-month-old Colorado boy’s death from a heart condition was likely related to ingestion of marijuana, two Denver doctors have concluded, but the precise link remains unclear.

Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency.
Cryptococcal meningitis is a life-threatening condition most commonly observed in immunocompromised individuals. We describe a daily cannabis smoker without evidence of immunodeficiency presenting with confirmed Cryptococcus neoformans meningitis. An investigation of cannabis samples from the patient's preferred dispensary demonstrated contamination with several varieties of Cryptococcus, including C. neoformans, and other opportunistic fungi. These findings raise concern regarding the safety of dispensary-grade cannabis, even in immunocompetent users.

New research reveals that several species, including the northern spotted owl, are succumbing to rat poison from thousands of "unpermitted private marijuana grow sites" in the northwestern California counties of Humboldt, Mendocino and Del Norte.
It's the contamination of the owls' primary food source — mice and rats, which, like humans, are attracted to the aromatic crop — that has been the animals' undoing: Scientists from the University of California, Davis, and the California Academy of Sciences have detected traces of anticoagulant rodenticide in seven of the 10 northern spotted owl carcasses they collected, according to a study published today (Jan. 11) in the journal Avian Conservation and Ecology.

“Every statistical study has seen an increase in marijuana use,” he said. “There has been an increase in youths going to rehab for addiction to marijuana. There have been increases in car accidents. There has been an increase in fatalities related to marijuana. There has been an increase in workplace incidences related to marijuana and a decrease in productivity. And there has been an increase in robberies.”
“There has been nothing good for Colorado, except for maybe the increased tax revenue. But even then, it is a mixed bag. Many people have moved to Colorado to exploit legalized marijuana — so housing prices have increased. There is more traffic downtown. You can find marijuana dispensaries all over the place, especially in the poorer parts of town. It is becoming part of the state’s subculture,” said Brugger.
The smell of marijuana is ubiquitous in the state now — so much so that there has been a marked increase in complaints to the police about the smell.
For those who own ski resorts, the emergence of marijuana smokers has been troubling, according to Brugger.

A team of law enforcement agents from the U.S. Forest Service, local police and the U.S. Fish and Wildlife Service hike deep into the Plumas National Forest to help with cleanup and protect scientists who are studying illegal marijuana grow sites. Even after a site has been raided, growers can return. The nets are for helicopters that will lift tons of garbage out of the site. On this reclamation trip, teams ultimately cleaned up about 7 tons of garbage, 4,000 pounds of fertilize, and 4 miles of irrigation tube, and they found the carcasses of three black bears, one grey fox and several rodents and birds. This accounts for just four sites.
14,000 Pounds of Rodenticide
Hours north of Calaveras, deep in public forests along the California-Oregon border, 12 tons of plastic trash, thousands of pounds of fertilizers and more than 80 pounds of toxic rodenticides and pesticides lay strewn among towering pines and oaks—turning this Eden into a landfill.

But she didn't have cancer. She had an obscure syndrome called cannabinoid hyperemesis syndrome, a condition only recently acknowledged by the medical community. It affects a small population — namely, a subset of marijuana users who smoke multiple times a day for months, years or even decades.

There's no hard data on the prevalence of the illness. But in California and Colorado, which have loosened marijuana laws in recent years, some emergency physicians say they're seeing it more often. One study in Colorado suggests there may be a link.

bstract

Although recent Cannabis use is widely reported to be associated with drug-related traffic accidents, the evidence that Cannabis users show an increased risk of being involved in road crashes is still not unequivocally proved. The purpose of the present work is to provide an objective assessment of this hypothesis, by comparing the frequency of occurrence of positive urine analyses in drivers involved in traffic accidents (n = 1406) with that observed in a control population undergoing mandatory urine drug testing (n = 1953). Urine analyses for drugs of abuse were performed by screening immunometric techniques followed by confirmation with UHPLC-QQQ MS, adopting a cut-off concentration for THC-COOH of 15 ng/mL. A case was classified as "positive" when a driver admitted to hospital for road traffic injuries showed urine concentrations of THC-COOH higher than the cut-off. All samples showing positive results for any other controlled drug in urine or blood alcohol concentrations >0.5 mg/mL were excluded from the study. Subjects positive to THC-COOH, and negative to all the other tested substances were 116 in Group 1 (8.2%) and 16 in Group 2 (0.8%). Subjects resulting negative to any tested substances were 1290 in Group 1 and 1937 in Group 2. The frequency of THC-COOH detection in the two groups was compared by using the "chi square" test, which resulted = 119.57, i.e. highly significant (P <<< 0.01). The Odds Ratio of the two groups was =10.88, showing a high degree of association between the presence of THC-COOH in urine and the occurrence of traffic accidents (P < 0.0001). The presented data, proving a high degree of association between Cannabis use and the occurrence of traffic accidents with injuries of the driver, support the use of urine testing for Cannabis in the procedures for the issuing of the driving licence, particularly in the case of subjects formerly or presently using Cannabis. This finding looks even more relevant in the present times, because of the increasing success of the policies of legalization of Cannabis for medical and non-medical purposes.

Law enforcement officials applauded Sessions' move.

"We applaud the Attorney General for this action today that brings clarity on enforcement of the law by rescinding a confusing policy brought on by the previous administration that hindered law enforcement. This will allow sheriffs to carry out their mission of upholding the rule of law and keeping their communities safe," said National Sheriffs' Association President Harold Eavenson and Executive Director Jonathan Thompson in a statement.

WASHINGTON - The Department of Justice today issued a memo on federal marijuana enforcement policy announcing a return to the rule of law and the rescission of previous guidance documents. Since the passage of the Controlled Substances Act (CSA) in 1970, Congress has generally prohibited the cultivation, distribution, and possession of marijuana.
In the memorandum, Attorney General Jeff Sessions directs all U.S. Attorneys to enforce the laws enacted by Congress and to follow well-established principles when pursuing prosecutions related to marijuana activities. This return to the rule of law is also a return of trust and local control to federal prosecutors who know where and how to deploy Justice Department resources most effectively to reduce violent crime, stem the tide of the drug crisis, and dismantle criminal gangs.
"It is the mission of the Department of Justice to enforce the laws of the United States, and the previous issuance of guidance undermines the rule of law and the ability of our local, state, tribal, and federal law enforcement partners to carry out this mission," said Attorney General Jeff Sessions. "Therefore, today's memo on federal marijuana enforcement simply directs all U.S. Attorneys to use previously established prosecutorial principles that provide them all the necessary tools to disrupt criminal organizations, tackle the growing drug crisis, and thwart violent crime across our country."

Conclusions:

Cannabis use appears to increase rather than decrease the risk of developing nonmedical prescription opioid use and opioid use disorder.