Schizophrenia

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Title/Link
Link between cannabis use and schizophrenia is likely causal, especially for teens 06/01/2025	Of 18 total studies, 10 met all of the criteria. All studies reported an increased risk for psychosis-like events or schizophrenia, and in nine of the ten studies there was a significant increase. Overall, the odds ratio of developing psychosis like events or schizophrenia was 2.88. If the cannabis use occurred during adolescence, the risk was two times higher. The Hill criteria indicated a high likelihood for the contribution of cannabis to schizophrenia development. (The Bradford Hill criteria are used in epidemiology to evaluate the strength of evidence for a causal relationship between an exposure and an outcome.) Schizophrenia, cannabis-induced psychosis
Adolescent cannabis use and later development of schizophrenia: An updated systematic review of longitudinal studies 01/01/2022	Both high- and low-frequency marijuana usage were associated with a significantly increased risk of schizophrenia. The frequency of use among high- and low-frequency users is similar in both, demonstrating statistically significant increased risk in developing schizophrenia. mental health, Schizophrenia, youth
Cannabinoid Shows Positive Results in Treating Schizophrenia 09/15/2015	Positive top-line results have been reported from an exploratory phase 2a placebo-controlled clinical trial of cannabidiol (CBD, GW Pharmaceuticals) in patients with schizophrenia who had failed to respond adequately to first-line antipsychotic medications. DOES NOT CONTAIN THC. Schizophrenia, gw pharm, CBD
Cannabis use may influence cortical maturation in adolescent males 08/15/2015	Male teens who experiment with cannabis before age 16, and have a high genetic risk for schizophrenia, show a different brain development trajectory than low risk peers who use cannabis. Schizophrenia, males
How Cannabis Causes Paranoia: Using the Intravenous Administration of Δ9-Tetrahydrocannabinol (THC) to Identify Key Cognitive Mechanisms Leading to Paranoia 07/10/2015	The principal psychoactive constituent of cannabis is Δ9-tetrahydrocannabinol (THC). THC administered intravenously is characterized by the appearance of psychopharmocological effects within 5 minutes, which continue for at least 90 minutes, providing an excellent experimental window.[12] In within-subjects tests with nonclinical volunteers, D'Souza, in particular, has shown that intravenous administration of THC causes schizophrenia-like symptoms, perceptual disturbances, anxiety, and impaired working memory (eg, Morrison et al[13] and D'Souza et al[14,15]). Similar but more pronounced results were found in patients with schizophrenia.[15] Schizophrenia, paranoia, Studies, Research
Teen cannabis users have poor long-term memory in adulthood 03/12/2015	The study is among the first to say the hippocampus is shaped differently in heavy marijuana smokers and the different looking shape is directly related to poor long-term memory performance. The study also found that young adults with schizophrenia who abused cannabis as teens performed about 26 percent more poorly on memory tests than young adults with schizophrenia who never abused cannabis. youth, memory, Schizophrenia
tudy finds genetic links between schizophrenia and cannabis use 06/24/2014	Schizophrenia
Cannabis Use during Adolescent Development: Susceptibility to Psychiatric Illness 10/13/2013	adolescent, Psychiatric, addiction, Schizophrenia, opioid, Studies
Teens who smoke pot at risk for later schizophrenia, psychosis 03/08/2011	Evidence is mounting that regular marijuana use increases the chance that a teenager will develop psychosis, a pattern of unusual thoughts or perceptions, such as believing the television is transmitting secret messages. It also increases the risk of developing schizophrenia, a disabling brain disorder that not only causes psychosis, but also problems concentrating and loss of emotional expression. Teens, Schizophrenia
Documentary Links Marijuana Use with Psychosis, Schizophrenia 01/28/2010	Psychosis, Schizophrenia