THC exposure during adolescence may cause microglial cell death and brain changes, increasing schizophrenia risks in genetically susceptible individuals.
Earlier, a 2023 study found heavy marijuana use may trigger schizophrenia, particularly in young men. This study examined the health records of nearly 7 million Danish citizens and determined that up to 30% of schizophrenia diagnoses — around 3,000 in total — could have been prevented if young men hadn’t abused marijuana.