What is the bottom line for information that a person with Parkinson’s disease will need to know if considering medical marijuana. Marijuana should never be thought of as a replacement for dopaminergic and other approved therapies for Parkinson’s disease. Second, though most available large studies have not shown a benefit, that does not mean that there will not be a benefit. Much more research will be needed to understand which patients, which symptoms, and how best to safely administer medical marijuana in Parkinson’s disease, especially over the long-term. It may turn out that non-motor features such as depression, anxiety, and pain respond best, but studies are desperately needed to sort this out.