The Futile Search for the “Right” THC per se Level

THC is a large, fat-soluble molecule whose concentration in the blood rapidly drops as it is sequestered into the body’s fat stores, including the brain.  Immediately after smoking a joint, the THC level will be very high in the blood and very low in the brain.  The THC level in the brain climbs rapidly at the same time that as it is declining in the blood.  At some point, the concentrations cross, and the concentration continues to rise in the brain while it is still declining in the blood, since the brain acts like a sponge, soaking up the partially insoluble THC from the blood.