study

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Title
Subchronic toxicity of cannabis leaves on male albino rats
12/02/2023

Abstract Cannabis is the most commonly abused drug in the world. In Egypt, the Anti Narcotic General Administration showed that the narcotics problem costs the Egyptian economy approximately 800 million dollars annually. LD50, lethal dose that kills 50% of the treated animals, of the bango was determined and then selected groups of rats were given tenth of LD50 for 90 days.
All over the world, there is growing interest in the part played by drugs in traffic accidents, and how to investigate adequate measures to reduce their incidence.2 Africa is the second largest producer of herbal cannabis in the world.3 In Egypt, drug addiction is considered one of the serious problems that worry both people and government. It affects young people within their productive years. It may lead to many problems such as social maladaptation, decreased works productivity and job loss.4 ‘Bango’ is the name of cannabis leaves used in Egypt and North Africa.5
Conclusion In conclusion, the present study revealed the bad effects of the bango plant on different organs in animals. Bango abuse leads to severe effects on different organs and this may subsequently lead to apoptosis and fibrosis of the organs, and this depends mainly on the dose and duration of administration.


study, Research, rats
CANNABIS: DRUG OF ABUSE AND THERAPEUTIC AGENT, TWO SIDES OF THE SAME COIN
05/27/2023

The evidence presented in this review allows us to conclude that Δ9-THC and CBD produce biphasic, dose-dependent effects on several physiological responses. The biphasic nature of cannabinoid effects highlights the need for a careful analysis of the dose ranges separating therapeutic from unwanted effects. Besides, Δ9-THC produces dependence and harmful effects, while CBD does not.
The available pharmaceutical formulations of these phytocannabinoids and related molecules have clear therapeutic effects; however, more research is needed to assure their efficacy and safety since their effects are complex. Several additional potential therapeutic applications, mainly for CBD, are being proposed which, however, still lack sufficient clinical and preclinical support. For this reason, caution is advised when using or prescribing cannabinoids.
Additional consideration deserves the fact that the ECS participates in the development of the central nervous system98. Therefore, the use of cannabinoid-based formulations for the medical treatment of children and adolescents experiencing brain developmental changes must be carefully examined, balancing the pros and cons of prescribing cannabinoid-based medications in every single case. Cannabis research field is expanding with the identification of new molecular targets, the characterization of undescribed phytocannabinoids, and novel findings related to the ECS99. In addition, consumption of synthetic cannabinoids as drugs of abuse represents a new challenge in addiction research100.


Potency, study, Research, THC levels
Intensity of cannabis use: Findings from three online surveys
01/17/2023
study
Cannabis For Pain Relief? Review of 20 Studies Provides Sobering Results
12/01/2022

There are numerous examples of the relationship between treatment expectations and placebo responses. If a person thinks they will experience relief from their pain by using a certain product or treatment, this can change the way they end up perceiving incoming pain signals – making them think their pain is less severe. Recent evidence suggests that the placebo effect may work even if we're presented with evidence that contradicts our initial expectations.
We cannot say with 100 percent certainty that media coverage is responsible for the high placebo response observed in our review. But given placebos were shown to be just as good as cannabis for managing pain, our results show just how important it is to think about the placebo effect and how it can be influenced by external factors – such as media coverage.


study, Placebo, sciencealert
Association of Mental Health Burden With Prenatal Cannabis Exposure From Childhood to Early Adolescence: Longitudinal Findings From the Adolescent Brain Cognitive Development (ABCD) Study
12/01/2022

Conclusions and relevance: This study suggests that prenatal cannabis exposure and its correlated factors are associated with greater risk for psychopathology during middle childhood. Cannabis use during pregnancy should be discouraged.     


prenatal, Pregnancy, mental health, study, Research, 2023 Presentation Dr Berry
Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
11/20/2022

Conclusions: This is the first characterization of the effect of cannabis exposure on the entirety of the rat sperm methylome. We identified CE-associated methylation changes across the sperm methylome, some of which persisted despite a "washout" period. Select methylation changes validated via bisulfite pyrosequencing, and genes associated with methylation changes were involved in early developmental processes. Preconception CE exposure is associated with detectable changes in offspring DNA methylation that are functionally related to changes in gene expression and cardiomegaly. These results support that paternal preconception exposure to cannabis can influence offspring outcomes.     


study, Research, rats, offspring, heredity, 2023 Presentation Dr Berry
Placebo Response and Media Attention in Randomized Clinical Trials Assessing Cannabis-Based Therapies for Pain
11/16/2022

Findings  This meta-analysis of 20 studies of 1459 individuals found a significant pain reduction in response to placebo in cannabinoid randomized clinical trials. Media attention was proportionally high, with a strong positive bias, yet not associated with the clinical outcomes.
Meaning  These findings suggest that placebo has a significant association with pain reduction as seen in cannabinoid clinical trials, and the positive media attention may shape placebo responses in future trials.


Placebo, meta-analysis, JAMA, 2023 Presentation Dr Berry, study, Research
What is Delta-8? Cleveland Clinic
06/26/2022

Like CBD, delta-8 (delta-8 tetrahydrocannabinol) is just one of more than 100 chemical compounds found in the cannabis sativa plant. Most people are familiar with THC (delta-9 tetrahydrocannabinol), the main psychoactive compound in cannabis that gives you a euphoric high.
The 2018 Farm Bill legalized the production and sale of CBD products (which don’t get you high) on the federal level in the U.S. as long as they contain less than .3% of THC. In theory, this would allow federal legalization of CBD products with delta-8 under those same guidelines, but doctors, like internal medicine specialist Paul Terpeluk, DO, are expressing concerns about delta-8 products because delta-8 is psychoactive and produces same or similar highs as THC.


Delta-8, study
Associations of Cannabis Use across Adolescence and Early Adulthood With Health and Psychosocial Adjustment
06/13/2022

 

 

Associations of Cannabis Use across Adolescence and Early Adulthood With Health and Psychosocial Adjustment in Early Adulthood and Midadulthood in Men
Results: Whereas there was almost no prediction from prior cannabis use to the physical health outcomes, there were comprehensive associations of cannabis use from the prior developmental period and psychosocial outcomes in both early adulthood and midadulthood.
Conclusion: Cannabis use in prior developmental periods was associated with a broad range of types of poor psychosocial adjustment in adulthood.


cannabis-induced psychosis, men, young adults, study, PubMed
Delta-8 THC use in US adults: Sociodemographic characteristics and correlates
06/13/2022

Conclusions
Findings provide initial insight into the current state of Delta-8 THC use in the US. Given the limited knowledge on use of Delta-8 THC, and considering emergence of reports indicating its harmful effects, there is urgent need for nationally representative data to investigate correlates of Delta-8 THC use (e.g., effectiveness of state-specific restrictions on its products). Such information can guide public-health policy around Delta-8 THC use.


Delta-8, study
Marijuana for medical use may result in rapid onset of cannabis use disorder
03/24/2022
  • A new study shows that using cannabis products to treat pain, anxiety and depression failed to improve these symptoms while doubling the risk of developing the addictive symptoms of cannabis use disorder.
  • People seeking cannabis to treat symptoms of anxiety and depression were at greatest risk of CUD.
  • Contrary to evidence-based medicine, people with medical marijuana cards choose their own products and dosing, suggesting the need for better controls over dispensing, use, and professional follow-up of these patients.

CUD, 'medicine', study
Cannabis use may be associated with suicidality in young adults
06/01/2021

An analysis of survey data from more than 280,000 young adults ages 18-35 showed that cannabis (marijuana) use was associated with increased risks of thoughts of suicide (suicidal ideation), suicide plan, and suicide attempt. These associations remained regardless of whether someone was also experiencing depression, and the risks were greater for women than for men.
“Suicide is a leading cause of death among young adults in the United States, and the findings of this study offer important information that may help us reduce this risk,”


youth, suicide, NIH, study, Research
Largest brain study of 62,454 scans identifies drivers of brain aging
05/01/2019

The study found that a number of brain disorders and behaviors predicted accelerated aging, especially schizophrenia, which showed an average of 4 years of premature aging, cannabis abuse (2.8 years of accelerated aging), bipolar disorder (1.6 years accelerated aging), ADHD (1.4 years accelerated aging) and alcohol abuse (0.6 years accelerated aging). Interestingly, the researchers did not observe accelerated aging in depression and aging, which they hypothesize may be due to different types of brain patterns for these disorders.


study, Brain, aging, science daily
cannabis use to variation in the incidence of psychotic disorder across Europe
03/19/2019

In conclusion, our findings confirm previous evidence of the harmful effect on mental health of daily use of cannabis, especially of high-potency types. Importantly, they indicate for the first time how cannabis use affects the incidence of psychotic disorder. Therefore, it is of public health importance to acknowledge alongside the potential medicinal properties of some cannabis constituents the potential adverse effects that are associated with daily cannabis use, especially of high-potency varieties.


Research, study, Lancet, Potency, Psychosis, cannabis-induced psychosis
Daily Marijuana Use And Highly Potent Weed Linked To Psychosis
03/19/2019

The study authors consider high-potency cannabis to be products with more than 10 percent tetrahydrocannabinol or THC, the compound responsible for the drug's psychoactive effects. The fact that consuming high-THC cannabis products has a greater risk is concerning, Lisdahl says, because these products are more common in the market now.

Now a new study published Tuesday in the The Lancet Psychiatry shows that consuming pot on a daily basis and especially using high-potency cannabis increases the odds of having a psychotic episode later.


study, Potency, Lancet, Psychosis
Children of mothers
09/24/2018

When mothers use marijuana during the first 12 years of their child's life, their cannabis-using children are more likely to start at an earlier age than children of non-using mothers, according to a new study from the Harvard T.H. Chan School of Public Health published in the American Journal of Preventive Medicine. This study is the first to establish a relationship between maternal cannabis use during a child's lifetime and earlier initiation in a nationally-representative, longitudinal cohort and examine the role of race, gender, and other social environmental factors.


Children, parents, study
4-year prospective cohort study
09/13/2018

In conclusion, cannabis use is common in people with chronic non-cancer pain who have been prescribed opioids, and interest in medicinal use of cannabis is increasing. We found no evidence that cannabis use improved patient outcomes; those who used cannabis had greater pain and lower self-efficacy in managing pain. Furthermore, we found no evidence that cannabis use reduced pain interference or exerted an opioidsparing effect.


Lancet, study, pain
Cannabis use and driving-related performance
07/01/2018

We found that among young recreational cannabis users, a regular dose of cannabis had no effect on simple and learned tasks, but its use led to significant impairments on complex and novel driving-related tasks, as well as perceived driving ability and safety, for up to 5 hours after use. The present finding that the first 5 hours after cannabis use affected driving-related performance substantiates the recommendations of Canada’s Lower-Risk Cannabis Use Guidelines, which recommend waiting 6 hours after cannabis use before driving.30
 


Canada, Research, study, driving, youth
Study shows prenatal cannabis use associated with low birth weights
04/23/2018

They also discovered that prenatal marijuana use was associated with a 50 percent increased chance of low birth weight regardless of tobacco use during pregnancy. “Growing evidence suggests prenatal cannabis exposure has a detrimental impact on offspring brain function starting in the toddler years, specifically issues related to attention deficit disorder,” Crume said. “But much of the research on the effects of prenatal cannabis on neonatal outcomes was based on marijuana exposures in the 1980s and 1990s which may not reflect the potency of today’s cannabis or the many ways it is used.”

 


Pregnancy, study
Medical Marijuana Users are More Likely to Use Prescription Drugs Medically and Nonmedically
04/17/2018

Conclusions: Our findings disconfirm the hypothesis that a population-level negative correlation between medical marijuana use and prescription drug harms occurs because medical marijuana users are less likely to use prescription drugs, either medically or nonmedically. Medical marijuana users should be a target population in efforts to combat nonmedical prescription drug use.


opioid, study, Research
Pathway to Heroin
03/03/2018


heroin, addiction, study
Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency.
01/31/2018

Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency.
Cryptococcal meningitis is a life-threatening condition most commonly observed in immunocompromised individuals. We describe a daily cannabis smoker without evidence of immunodeficiency presenting with confirmed Cryptococcus neoformans meningitis. An investigation of cannabis samples from the patient's preferred dispensary demonstrated contamination with several varieties of Cryptococcus, including C. neoformans, and other opportunistic fungi. These findings raise concern regarding the safety of dispensary-grade cannabis, even in immunocompetent users.


Cryptococcal meningitis, chronic, study, PubMed
Systematic review of safeness and therapeutic efficacy of cannabis
11/16/2017

there is incomplete evidence of the efficacy and safety of medical use of cannabis in the clinical contexts considered in this review. Furthermore, for many of the outcomes considered, the confidence in the estimate of the effect was again low or very low. To give conclusive answers to the efficacy and safety of cannabis used for medical purposes in the clinical contexts considered, further studies are needed, with higher quality, larger sample sizes, and possibly using the same diagnostic tools for evaluating outcomes of interest.


study, 'medicine', MS, Chemo
Secondhand Pot Smoke Just As Bad For Heart As Tobacco
08/21/2017

The main finding was that when rats were exposed to secondhand smoke from marijuana for one minute, their arteries became less efficient at carrying enough blood for at least 90 minutes, whereas similar exposure to secondhand smoke from tobacco caused impairment that fully recovered within 30 minutes (exposure to clean air in the exposure chamber did not cause impairment). (It is important to understand that arteries of rats and humans are similar in how they respond to tobacco smoke, so the response of rat arteries to marijuana smoke is expected to be a valid indication of how human arteries respond to marijuana smoke.)


study, second hand smoke
Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review
08/01/2017

"We found no observational studies that met inclusion criteria, but a growing body of cross-sectional literature suggests negative opioid-related correlates among individuals who use cannabis and opioids concurrently. These include opioid misuse;9,10,99,133 a greater number of opioid refills;99 a longer duration of opioid use; a higher dose of opioid medication prescribed;9 and endorsement of using opioids and other pain medications without a prescription.134"


Veterans, opioid, study
Cognitive control in young adults with cannabis use disorder: An event-related brain potential study.
07/26/2017

Abstract

Contemporary models of substance use disorders emphasize the role of cognitive control, which has been linked to difficulties in resisting the use of substances. In the present study, we measured two aspects of cognitive control, response inhibition (operationalized by a Go/NoGo Task) and performance monitoring (operationalized by an Eriksen Flanker Task), in a group of young cannabis-use disorder (CUD) patients and compared these functions with two control groups (i.e. a group of cigarette smokers and a group of non-smokers). We employed both behavioural and electrophysiological measures. The results indicate that CUD patients displayed reduced NoGo-P3 event-related potentials compared with non-smoking controls, but not compared with smoking controls. In addition, CUD patients were slower on Go trials than both control groups. No other between-group electrophysiological or behavioural differences were observed. These results seem to suggest that CUD patients have problems related to response inhibition, but performance monitoring seems relatively unaffected.

 


CUD, Cannabis-use disorder, study
School Of Public Health Study Finds Use Of Marijuana Increases Risk Of Metabolic Syndrome School Of Public Health Study Finds Use Of Marijuana Increases Risk Of Metabolic Syndrome
06/29/2017

“Duration of marijuana use seems to be a significant factor associated with metabolic syndrome,” the researchers said.
Metabolic syndrome is a cluster of symptoms that increase a person’s risk for heart disease, stroke and diabetes.
The study found that “every year increase in marijuana use is associated with at least a 5 percent increase in odds of having metabolic syndrome.”


study, Georgia State University, Metabolic Syndrome
Patterns of cannabis use during adolescence and their association with harmful substance use behaviour: findings from a UK birth cohort
06/07/2017

Conclusions One-fifth of the adolescents in our sample followed a pattern of occasional or regular cannabis use, and these young people were more likely to progress to harmful substance use behaviors in early adulthood.


study, longitudinal, PubMed
Teen Pot Use Linked to Illegal Drug Use by Age 21, Study Suggests
06/07/2017

In the new study, researchers analyzed data from the Avon Longitudinal Study of Parents and Children, a long-running study in the U.K. that has followed women and their children. The study began when the women were first pregnant, all in 1991 or 1992.
For the new report, the researchers looked at questionnaires that more than 5,300 of the children completed. The kids were surveyed at least three times between ages 13 and 18, and asked about the frequency of their use of drugs, alcohol and tobacco in the previous three monthsThey were also sent a follow-up survey by mail to measure these behaviors at age 21.
Researchers found that teenagers in the study who regularly used marijuana were 26 times more likely to have used other illegal drugs, such as cocaine, amphetamines or hallucinogens, by the time they reached early adulthood, compared with teens who hadn't smoked pot, according to the findings published online today (June 7) in the Journal of Epidemiology and Community Health.


study, longitudinal, UK, gateway
Medical marijuana: Fungal, bacterial contaminants found, dangerous for immunocompromised patients
02/27/2017

UC Davis physician researchers have found that medical marijuana contains multiple bacterial and fungal pathogens that may cause serious and even fatal infections. They warn that smoking, vaping or inhaling aerosolized marijuana could pose a grave risk to patients, especially those with leukemia, lymphoma, AIDS or conditions requiring immune-suppressing therapies.
 
“Infection with the pathogens we found in medical marijuana could lead to serious illness and even death,” said Joseph Tuscano, a professor of internal medicine in the Division of Hematology and Oncology at UC Davis, and a lead study author. “Inhaling marijuana in any form provides a direct portal of entry deep into the lungs where infection can easily take hold.”


contaminated, UC Davis, study
Health Effects of Marijuana and Cannabis
01/20/2017

The evidence reviewed by the committee suggests that cannabis use is likely to increase the risk of developing schizophrenia, other psychoses, and social anxiety disorders, and to a lesser extent depression.   Heavy cannabis users are more likely to report thoughts of suicide than non-users, and in individuals with bipolar disorder, near-daily cannabis users show increased symptoms of the disorder than non-users.


mental health, smoking, study, science engineering medicine, 2019 legislation
Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood
02/16/2010

Conclusions and Relevance  Although individual-level risk remains moderate to low and results from this study should be confirmed in future adequately powered prospective studies, the high prevalence of adolescents consuming cannabis generates a large number of young people who could develop depression and suicidality attributable to cannabis. This is an important public health problem and concern, which should be properly addressed by health care policy.


anxiety, depression, suicide, study, meta-analysis, Research, 2023 Presentation Dr Berry
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